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Academic Journal

Ketoheterocycle-based inhibitors of cathepsin K: A novel entry into the synthesis of peptidic ketoheterocycles

Authors : Tavares, Francis X.; Deaton, David N.; Miller, Aaron B.

Source: Bioorganic & Medicinal Chemistry Letters. Sept 1, 2005, Vol. 15 Issue 17, p3891, 5 p.

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Academic Journal

Oxidation of oxazolines and thiazolines to oxazoles and thiazoles. Application of the Kharasch-Sosnovsky reaction

Authors : Meyers, A.I.; Tavares, Francis X.

Source: Journal of Organic Chemistry. Nov 15, 1996, Vol. 61 Issue 23, p8207, 9 p. table

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Academic Journal

Structure-activity relationships and cellular mechanism of action of small molecules that enhance the delivery of oligonucleotides.

Authors : Juliano, Rudolph L; Wang, Ling; Tavares, Francis

Source: Nucleic Acids Research; 2/28/2018, Vol. 46 Issue 4, p1601-1613, 13p

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Academic Journal

Total synthesis of streptogramin antibiotics: (-)-madumycin II

Authors : Tavares, Francis; Lawson, Jon P.; Meyers, A.I.

Source: Journal of the American Chemical Society. April 3, 1996, Vol. 118 Issue 13, p3303, 2 p.

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Academic Journal

A New and Convenient Synthesis of 3(2 H )-Pyridazinones by Reacting Carbanion of Ethyl Trimethylsilylacetate with Phenylhydrazones.

Authors : Patel, Himatkumar V.; Vyas, Kavita A.; Pandey, Sudhanshu P.

Source: Synthetic Communications; Sep1991, Vol. 21 Issue 18/19, p1935-1940, 6p

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Academic Journal

Concise and Efficient Synthesis of 1 H -Pyrazoles: Reaction of [Hydroxy(tosyloxy)iodo]benzene with Ethyl 2,3-Dioxobutanoate-2-arylhydrazones.

Authors : Patel, Himatkumar V.; Vyas, Kavita A.; Pandey, Sudhanshu P.

Source: Synthetic Communications; Aug1991, Vol. 21 Issue 15/16, p1583-1588, 6p

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Academic Journal

Reaction of Triethyl Phosphonoacetate Anion with Phenylhydrazones: A New Method for the Preparation of 3(2 H )-Pyridazinones.

Authors : Patel, Himatkumar V.; Vyas, Kavita A.; Pandey, Sudhanshu P.

Source: Synthetic Communications; Apr1991, Vol. 21 Issue 8/9, p1021-1026, 6p

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Periodical

6-(4-Chlorophenyl)-3-substituted-thieno3,2-dpyrimidin-4(3H)-one-Based Melanin-Concentrating Hormone Receptor 1 Antagonist

Authors : X. Tavares, Francis; A. Al-Barazanji, Kamal; J. Bishop, Michael

Source: Journal of Medicinal Chemistry; November 2006, Vol. 49 Issue: 24 p7108-7118, 11p

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Periodical

Potent, Selective, and Orally Efficacious Antagonists of Melanin-Concentrating Hormone Receptor 1

Authors : X. Tavares, Francis; A. Al-Barazanji, Kamal; C. Bigham, Eric

Source: Journal of Medicinal Chemistry; November 2006, Vol. 49 Issue: 24 p7095-7107, 13p

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Periodical

Design of Cathepsin K Inhibitors for Osteoporosis

Authors : Deaton, David; Tavares, Francis

Source: Current Topics in Medicinal Chemistry; December 2005, Vol. 5 Issue: 16 p1639-1675, 37p

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Periodical

Enantioselective synthesis of a taxane C-ring component using the Schultz asymmetric Birch reduction methodology

Authors : Magnus, Philip; Tavares, Francis; Westwood, Nicholas

Source: Tetrahedron Letters; January 1997, Vol. 38 Issue: 8 p1341-1344, 4p

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Periodical

Reaction of Triethyl Phosphonoacetate Anion with Phenylhydrazones: A New Method for the Preparation of 3(2H)-Pyridazinones

Authors : Patel, Himatkumar; Vyas, Kavita; Pandey, Sudhanshu

Source: Synthetic Communications; April 1991, Vol. 21 Issue: 8 p1021-1026, 6p

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Periodical

A New and Convenient Synthesis of 3(2H)-Pyridazinones by Reacting Carbanion of Ethyl Trimethylsilylacetate with Phenylhydrazones

Authors : Patel, Himatkumar; Vyas, Kavita; Pandey, Sudhanshu

Source: Synthetic Communications; September 1991, Vol. 21 Issue: 18 p1935-1940, 6p

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Periodical

Concise and Efficient Synthesis of 1H-Pyrazoles: Reaction of [Hydroxy(tosyloxy)iodo]benzene with Ethyl 2,3-Dioxobutanoate-2-arylhydrazones

Authors : Patel, Himatkumar; Vyas, Kavita; Pandey, Sudhanshu

Source: Synthetic Communications; August 1991, Vol. 21 Issue: 15 p1583-1588, 6p

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Academic Journal

A Facile Synthesis of 1-Arylpyrazoles by Reacting Diethyl (Ethylthiomethyl)phosphonate Carbanion with Arylhydrazones.

Authors : Patel, Himatkumar V.; Vyas, Kavita A.; Pandey, Sudhanshu P.

Source: Synlett; 1991, Vol. 1991 Issue 7, p483-484, 2p

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Academic Journal

Ketoheterocycle-Based Inhibitors of Cathepsin K: A Novel Entry into the Synthesis of Peptidic Ketoheterocycles.

Authors : Tavares, Francis X.; Deaton, David N.; Miller, Aaron B.

Source: ChemInform; Dec2005, Vol. 36 Issue 51, pno-no, 1p

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Academic Journal

Novel and Potent Cyclic Cyanamide-Based Cathepsin K Inhibitors.

Authors : Deaton, David N.; Hassell, Anne M.; McFadyen, Robert B.

Source: ChemInform; Jul2005, Vol. 36 Issue 30, pno-no, 1p

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Academic Journal

Orally Bioavailable Small Molecule Ketoamide-Based Inhibitors of Cathepsin K.

Authors : Barrett, David G.; Catalano, John G.; Deaton, David N.

Source: ChemInform; Sep2004, Vol. 35 Issue 39, pno-no, 1p

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Periodical

Editorial [Hot Topic: Protease Inhibitors in Drug Discovery (Guest Editor: Francis X. Tavares)]

Authors : Tavares, Francis

Source: Current Topics in Medicinal Chemistry; December 2005, Vol. 5 Issue: 16 p1587-1587, 1p

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Academic Journal

Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy

Authors : Thomson, Stephen A. ; Banker, Pierette¹; Bickett, D. Mark¹

Source: Bioorganic & Medicinal Chemistry Letters. Feb2009, Vol. 19 Issue 4, p1177-1182. 6p.

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Academic Journal

Anthranilimide-based glycogen phosphorylase inhibitors for the treatment of Type 2 diabetes: 2. Optimization of serine and threonine ether amino acid residues

Authors : Sparks, Steven M. ; Banker, Pierette¹; Bickett, David M.¹

Source: Bioorganic & Medicinal Chemistry Letters. Feb2009, Vol. 19 Issue 3, p981-985. 5p.

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Academic Journal

Anthranilimide-based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes: 1. Identification of 1-amino-1-cycloalkyl carboxylic acid headgroups

Authors : Sparks, Steven M. ; Banker, Pierette¹; Bickett, David M.¹

Source: Bioorganic & Medicinal Chemistry Letters. Feb2009, Vol. 19 Issue 3, p976-980. 5p.

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Academic Journal

Amino acid anthranilamide derivatives as a new class of glycogen phosphorylase inhibitors

Authors : Evans, Karen A.¹ ; Li, Yue H.¹; Coppo, Frank T.¹

Source: Bioorganic & Medicinal Chemistry Letters. Jul2008, Vol. 18 Issue 14, p4068-4071. 4p.

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Academic Journal

Acyclic, orally bioavailable ketone-based cathepsin K inhibitors

Authors : Barrett, David G.¹; Catalano, John G.¹; Deaton, David N.¹

Source: Bioorganic & Medicinal Chemistry Letters. Jan2007, Vol. 17 Issue 1, p22-27. 6p.

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Academic Journal

Synthesis and structure–activity relationships of 3-phenyl-2-propenamides as inhibitors of glycogen phosphorylase a

Authors : Li, Yue H.¹; Coppo, Frank T.¹; Evans, Karen A.¹

Source: Bioorganic & Medicinal Chemistry Letters. Nov2006, Vol. 16 Issue 22, p5892-5896. 5p.

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Academic Journal

The discovery and optimization of pyrimidinone-containing MCH R1 antagonists

Authors : Hertzog, Donald L. ; Al-Barazanji, Kamal A.¹; Bigham, Eric C.¹

Source: Bioorganic & Medicinal Chemistry Letters. Sep2006, Vol. 16 Issue 18, p4723-4727. 5p.

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Academic Journal

P2–P3 conformationally constrained ketoamide-based inhibitors of cathepsin K

Authors : Barrett, David G.¹; Boncek, Virginia M.²; Catalano, John G.¹

Source: Bioorganic & Medicinal Chemistry Letters. Aug2005, Vol. 15 Issue 15, p3540-3546. 7p.

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Academic Journal

Novel and potent cyclic cyanamide-based cathepsin K inhibitors

Authors : Deaton, David N.¹ ; Hassell, Anne M.²; McFadyen, Robert B.¹

Source: Bioorganic & Medicinal Chemistry Letters. Apr2005, Vol. 15 Issue 7, p1815-1819. 5p.

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Academic Journal

Orally bioavailable small molecule ketoamide-based inhibitors of cathepsin K

Authors : Barrett, David G.¹; Catalano, John G.¹; Deaton, David N.¹

Source: Bioorganic & Medicinal Chemistry Letters. May2004, Vol. 14 Issue 10, p2543. 4p.

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