Search Results

Development of BRD4 inhibitors as anti-inflammatory agents and antidotes for arsenicals

• Authors : Yatchang, Marina Fosso; Mathew, Bini; Srivastava, Ritesh K.

• Source: Bioorganic & Medicinal Chemistry Letters. May 15, 2022, Vol. 64

Record details

Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-O!B activators for the treatment of ALS

• Authors : Mathew, Bini; Ruiz, Pedro; Dutta, Shilpa

• Source: European Journal of Medicinal Chemistry. Jan 15, 2021, Vol. 210

Record details

Development and application of high-throughput screens for the discovery of compounds that disrupt ErbB4 signaling: Candidate cancer therapeutics

• Authors : Cullum, Richard L.; Lucas, Lauren M.; Senfeld, Jared I.

• Source: PLoS ONE. Dec 30, 2020, Vol. 15 Issue 12, e0243901

Record details

HBV Core Promoter Inhibition by Tubulin Polymerization Inhibitor (SRI-32007)

• Authors : Kalkeri, Raj; Peng, Junzhong; Huang, Chunsheng

• Source: Advances in Virology. October 14, 2020, Vol. 2020

Record details

Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action

• Authors : Thielen, Lance A.; Chen, Junqin; Jing, Gu

• Source: Cell Metabolism. Sept 1, 2020, Vol. 32 Issue 3, 353

Record details

Rational design and development of a peptide inhibitor for the PD-1/PD-L1 interaction

• Authors : Boohaker, Rebecca J.; Sambandam, Vijaya; Segura, Isaac

• Source: Cancer Letters. October 10, 2018, Vol. 434, 11

Record details

Thrombospondin-1 regulation of latent TGF-[beta] activation: A therapeutic target for fibrotic disease

• Authors : Murphy-Ullrich, Joanne E.; Suto, Mark J.

• Source: Matrix Biology. August, 2018, Vol. 68, p28.

Record details

SRI36160 is a specific inhibitor of Wnt/[beta]-catenin signaling in human pancreatic and colorectal cancer cells

• Authors : Li, Yonghe; Oliver, Patsy G.; Lu, Wenyan

• Source: Cancer Letters. March 28, 2017, Vol. 389, p41.

Record details

Identification of drugs to treat MPS I caused by nonsense mutations

• Authors : Bedwell, David; Gunn, Gwen; Siddiqui, Amna

• Source: Molecular Genetics and Metabolism. Jan-Feb, 2017, Vol. 120 Issue 1-2, pS25.

Record details

GLI1 Inhibitor SRI-38832 Attenuates Chemotherapeutic Resistance by Downregulating NBS1 Transcription in BRAFV600E Colorectal Cancer.

• Authors : Zhang, Ruowen; Ma, Jinlu; Avery, Justin T.

Subjects: COLORECTAL cancer; CANCER chemotherapy; DNA damage

• Source: Frontiers in Oncology; 2/28/2020, p1-16, 16p

Record details

Frizzled7 as an emerging target for cancer therapy

• Authors : King, Taj D.; Zhang, Wei; Suto, Mark J.

• Source: Cellular Signalling. April 2012, Vol. 24 Issue 4, p846, 6 p.

Record details

Studies on Dibenzylamines as Inhibitors of Venezuelan Equine Encephalitis Virus.

• Authors : Nguyen, Theresa H.; Haese, Nicole N.; Madadi, Nikhil

• Source: ACS Infectious Diseases; 12/13/2019, Vol. 5 Issue 12, p2014-2028, 15p

Record details

Development of small‐molecule tau‐SH3 interaction inhibitors that prevent amyloid‐β toxicity.

• Authors : Roth, Jonathan R; Rush, Travis; Pugh, Derian A

• Source: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2021 Supplement S9, Vol. 17, p1-1, 1p

Record details

Effects of PD 128763, a New Potent Inhibitor of Poly(ADP-Ribose) Polymerase, on X-Ray-Induced Cellular Recovery Processes in Chinese Hamster V79 Cells

• Authors : Arundel-Suto, Carla M.; Scavone, Sylvia V.; Turner, William R.

• Source: Radiation Research. 126(3):367-371

Record details

AlphaScreen HTS and live-cell bioluminescence resonance energy transfer (BRET) assays for identification of Tau-Fyn SH3 interaction inhibitors for alzheimer disease

• Authors : Cochran, J. Nicholas; Diggs, Pauleatha V.; Nebane, N. Miranda

• Source: Journal of Biomolecular Screening. Dec 2014, Vol. 19 Issue 10, 1338-1349

Record details

Synthesis of Boxazomycin B and related analogs

• Authors : Suto, Mark J.; Turner, William R.

• Source: Tetrahedron Letters. Oct 2, 1995, Vol. 36 Issue 40, p7213, 4 p.

Record details

Structure-activity relationships and cellular mechanism of action of small molecules that enhance the delivery of oligonucleotides.

• Authors : Juliano, Rudolph L; Wang, Ling; Tavares, Francis

• Source: Nucleic Acids Research; 2/28/2018, Vol. 46 Issue 4, p1601-1613, 13p

Record details

Predicting radiotherapy response for patients with soft tissue sarcoma by developing a molecular signature.

• Authors : ZAIXIANG TANG; QINGHUA ZENG; YAN LI

• Source: Oncology Reports; Nov2017, Vol. 38 Issue 5, p2814-2824, 11p

Record details

Rational design and development of a peptide inhibitor for the PD-1/PD-L1 interaction.

• Authors : Sambandam, Vijaya¹; Suto, Mark¹; Boohaker, Rebecca J.^1,2

• Source: Cancer Letters. Oct2018, Vol. 434, p11-21. 11p.

Record details

Thrombospondin-1 regulation of latent TGF-β activation: A therapeutic target for fibrotic disease.

• Authors : Murphy-Ullrich, Joanne E.¹ ; Suto, Mark J.²

• Source: Matrix Biology. Aug2018, Vol. 68, p28-43. 16p.

Record details

Discovery of Clinically Approved Agents That Promote Suppression of Cystic Fibrosis Transmembrane Conductance Regulator Nonsense Mutations.

• Authors : Mutyam, Venkateshwar; Ming Du; Xiaojiao Xue

Subjects: ANIMAL experimentation; CELL lines; CYSTIC fibrosis

• Source: American Journal of Respiratory & Critical Care Medicine; 11/1/2016, Vol. 194 Issue 9, p1092-1103, 12p, 1 Diagram, 1 Chart, 6 Graphs

Record details

Discovery of a novel inhibitor of kinesin-like protein KIFC1.

• Authors : Wei Zhang; Ling Zhai; Yimin Wang

Subjects: BREAST cancer treatment; CANCER cells; NEOPLASTIC cell transformation

• Source: Biochemical Journal; 4/15/2016, Vol. 473 Issue 8, p1027-1035, 9p

Record details

Consortia's critical role in developing medical countermeasures for re-emerging viral infections: a USA perspective.

• Authors : Everts, Maaike; Suto, Mark J; Painter, George R

• Source: Future Virology; Mar2016, Vol. 11 Issue 3, p187-195, 9p

Record details

Inhibition of Transforming Growth Factor-β Activation Diminishes Tumor Progression and Osteolytic Bone Disease in Mouse Models of Multiple Myeloma

• Authors : Lu, Ailing; Pallero, Manuel A.; Lei, Weiqi

• Source: American Journal of Pathology; March 2016, Vol. 186 Issue: 3 p678-690, 13p

Record details

A Historical Perspective

• Authors : Suto, Mark J.

Subjects: Biotechnology industry; Business; Pharmaceuticals and cosmetics industriesUnited States

• Source: BioPharm. Feb, 1998, Vol. 11 Issue 2, 28

Record details

Process Development andOptimization for Production of a Potassium Ion Channel Blocker, ICA-17043.

• Authors : Mobele, Bingidimi I.; Venkatraman, Sripathy; McNaughton-Smith, Grant

• Source: Organic Process Research & Development; Aug2012, Vol. 16 Issue 8, p1385-1392, 8p

Record details

Role of Adiponectin in the Metabolic Syndrome: Current Perspectives on its Modulation as a Treatment Strategy

• Authors : Padmalayam, Indira; Suto, Mark

• Source: Current Pharmaceutical Design; October 2013, Vol. 19 Issue: 32 p5755-5763, 9p

Record details

The wnt/β-catenin signaling pathway: A potential therapeutic target in the treatment of triple negative breast cancer.

• Authors : King, Taj D.; Suto, Mark J.; Li, Yonghe

• Source: Journal of Cellular Biochemistry; Jan2012, Vol. 113 Issue 1, p13-18, 6p

Record details

Design of a gene family screening library targeting G-protein coupled receptors

• Authors : Lamb, Michelle L. ; Bradley, Erin K.; Beaton, Graham

Subjects: Iterative methods (Mathematics); Genes; Proteins

• Source: Journal of Molecular Graphics & Modelling. Sep2004, Vol. 23 Issue 1, p15-21. 7p.

Record details

Synthesis of chiral 3-substituted-3-aminomethyl-pyrrolidines and related compounds.

• Authors : Suto, Mark J.; Turner, William R.; Kampf, Jeffrey W.

• Source: Journal of Heterocyclic Chemistry; Oct1992, Vol. 29 Issue 6, p1441-1448, 8p

Record details

Neuronal nicotinic acetylcholine receptors as drug targets

• Authors : Suto, Mark J; Zacharias, Niki

• Source: Expert Opinion on Therapeutic Targets; April 2004, Vol. 8 Issue: 2 p61-64, 4p

Record details

Retraction of "Design and Synthesis of Novel Cyclic Amine Benzimidazoles for the Treatment of Pancreatic Cancer".

• Authors : Pathak, Vibha; Augelli-Szafran, Corinne E.; Han-Xun Wei

• Source: Journal of Medicinal Chemistry; Sep2017, Vol. 60 Issue 17, p7615-7615, 1p

Record details

Traceless linker: Oxidative activation and displacement of a sulfur-based linker

• Authors : Gayo, Leah M.; Suto, Mark J.

• Source: Tetrahedron Letters; January 1997, Vol. 38 Issue: 2 p211-214, 4p

Record details

Ion-exchange resins for solution phase parallel synthesis of chemical libraries

• Authors : Gayo, Leah M.; Suto, Mark J.

• Source: Tetrahedron Letters; January 1997, Vol. 38 Issue: 4 p513-516, 4p

Record details

Preferential Inhibition of Wnt/β-Catenin Signaling by Novel Benzimidazole Compounds in Triple-Negative Breast Cancer.

• Authors : Gangrade, Abhishek; Pathak, Vibha; Augelli-Szafran, Corinne E.

Subjects: CATENINS; WNT signal transduction; BREAST cancer

• Source: International Journal of Molecular Sciences; May2018, Vol. 19 Issue 5, p1524, 1p, 1 Black and White Photograph, 4 Graphs

Record details

Use of pentafluorophenyl esters for one-pot protection/activation of amino and thiol carboxylic acids

• Authors : Gayo, Leah M.; Suto, Mark J.

• Source: Tetrahedron Letters; January 1996, Vol. 37 Issue: 28 p4915-4918, 4p

Record details

Antiarrhythmic Agents.

• Authors : Suto, Mark J.; Krafte, Douglas S.

• Source: Annual Reports in Medicinal Chemistry; 2006, Vol. 41, p10-10, 1p

Record details

ChemInform Abstract: Ion Exchange Resins for the Preparation of Amide Libraries.

• Authors : Suto, Mark J.

• Source: ChemInform; Dec2001, Vol. 32 Issue 51, pno-no, 1p

Record details

ChemInform Abstract: High-Throughput Purification Strategies.

• Authors : Suto, Mark J.

• Source: ChemInform; Dec2001, Vol. 32 Issue 50, pno-no, 1p

Record details

ChemInform Abstract: Novel Inhibitors of AP-1 and NF-ϰB Mediated Gene Expression: Structure-Activity Relationship Studies of Ethyl 4-[(3-Methyl-2,5-dioxo(3-pyrrolinyl))amino] -2-(trifluoromethyl)pyrimidine-5-carboxylate.

• Authors : Palanki, Moorthy S. S.; Erdman, Paul E.; Manning, Anthony M.

• Source: ChemInform; Oct2000, Vol. 31 Issue 44, pno-no, 1p

Record details

ChemInform Abstract: Developments in Solution-Phase Combinatorial Chemistry.

• Authors : Suto, Mark J.

• Source: ChemInform; Dec1999, Vol. 30 Issue 52, pno-no, 1p

Record details

Preface

• Authors : Suto, Mark J.

• Source: Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents; April 2002, Vol. 1 Issue: 1 pi-i, 1p

Record details

Identification of Small Molecule Inhibitors of Human Cytochrome c Oxidase That Target Chemoresistant Glioma Cells.

• Authors : Oliva, Claudia R.¹; Markert, Tahireh¹; Ross, Larry J.²

• Source: Journal of Biological Chemistry. 11/11/2016, Vol. 291 Issue 46, p24188-24199. 25p.

Record details

Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-ҡB activators for the treatment of ALS.

• Authors : Mathew, Bini¹ (AUTHOR) ; Ruiz, Pedro¹ (AUTHOR) ; Dutta, Shilpa¹ (AUTHOR)

• Source: European Journal of Medicinal Chemistry. Jan2021, Vol. 210, pN.PAG-N.PAG. 1p.

Record details

Unique Functional and Structural Properties of the LRRK2 Protein ATP-binding Pocket.

• Authors : Zhiyong Liu^1,2; Galemmo Jr., Robert A.³; Fraser, Kyle B.¹

• Source: Journal of Biological Chemistry. 11/21/2014, Vol. 289 Issue 47, p32937-32951. 15p.

Record details

Development of novel small molecules for the treatment of ALS.

• Authors : Mathew, Bini¹ (AUTHOR); Ruiz, Pedro¹ (AUTHOR); Pathak, Vibha¹ (AUTHOR)

• Source: Bioorganic & Medicinal Chemistry Letters. Feb2020, Vol. 30 Issue 4, pN.PAG-N.PAG. 1p.

Record details

The design and synthesis of novel orally active inhibitors of AP-1 and NF-κB mediated transcriptional activation. SAR of In vitro and In vivo studies

• Authors : Palanki, Moorthy S. S.¹ ; Erdman, Paul E.¹; Ren, Minghuan¹

• Source: Bioorganic & Medicinal Chemistry Letters. Nov2003, Vol. 13 Issue 22, p4077. 4p.

Record details

Triamterene normalizes glycosaminoglycan accumulation in an IDUA-W402X mouse model of MPS I (Hurler syndrome) via nonsense suppression.

• Authors : Bedwell, David¹; Siddiqui, Amna¹; Dundar, Halil¹

• Source: Molecular Genetics & Metabolism. Feb2019, Vol. 126 Issue 2, pS30-S30. 1p.

Record details

Retraction notice to "SRI36160 is a specific inhibitor of Wnt/-catenin signaling in human pancreatic and colorectal cancer cells" [Canc. Lett. 389C (2017) 41-48].

• Authors : Li, Yonghe¹; Oliver, Patsy G.²; Lu, Wenyan¹

• Source: Cancer Letters. May2018, Vol. 422, p131-131. 1p.

Record details