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Development of BRD4 inhibitors as anti-inflammatory agents and antidotes for arsenicals

• Authors : Yatchang, Marina Fosso; Mathew, Bini; Srivastava, Ritesh K.

• Source: Bioorganic & Medicinal Chemistry Letters. May 15, 2022, Vol. 64

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Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-O!B activators for the treatment of ALS

• Authors : Mathew, Bini; Ruiz, Pedro; Dutta, Shilpa

• Source: European Journal of Medicinal Chemistry. Jan 15, 2021, Vol. 210

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Development and application of high-throughput screens for the discovery of compounds that disrupt ErbB4 signaling: Candidate cancer therapeutics

• Authors : Cullum, Richard L.; Lucas, Lauren M.; Senfeld, Jared I.

• Source: PLoS ONE. Dec 30, 2020, Vol. 15 Issue 12, e0243901

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HBV Core Promoter Inhibition by Tubulin Polymerization Inhibitor (SRI-32007)

• Authors : Kalkeri, Raj; Peng, Junzhong; Huang, Chunsheng

• Source: Advances in Virology. October 14, 2020, Vol. 2020

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Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action

• Authors : Thielen, Lance A.; Chen, Junqin; Jing, Gu

• Source: Cell Metabolism. Sept 1, 2020, Vol. 32 Issue 3, 353

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Rational design and development of a peptide inhibitor for the PD-1/PD-L1 interaction

• Authors : Boohaker, Rebecca J.; Sambandam, Vijaya; Segura, Isaac

• Source: Cancer Letters. October 10, 2018, Vol. 434, 11

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Thrombospondin-1 regulation of latent TGF-[beta] activation: A therapeutic target for fibrotic disease

• Authors : Murphy-Ullrich, Joanne E.; Suto, Mark J.

• Source: Matrix Biology. August, 2018, Vol. 68, p28.

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SRI36160 is a specific inhibitor of Wnt/[beta]-catenin signaling in human pancreatic and colorectal cancer cells

• Authors : Li, Yonghe; Oliver, Patsy G.; Lu, Wenyan

• Source: Cancer Letters. March 28, 2017, Vol. 389, p41.

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Identification of drugs to treat MPS I caused by nonsense mutations

• Authors : Bedwell, David; Gunn, Gwen; Siddiqui, Amna

• Source: Molecular Genetics and Metabolism. Jan-Feb, 2017, Vol. 120 Issue 1-2, pS25.

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GLI1 Inhibitor SRI-38832 Attenuates Chemotherapeutic Resistance by Downregulating NBS1 Transcription in BRAFV600E Colorectal Cancer.

• Authors : Zhang, Ruowen; Ma, Jinlu; Avery, Justin T.

Subjects: COLORECTAL cancer; CANCER chemotherapy; DNA damage

• Source: Frontiers in Oncology; 2/28/2020, p1-16, 16p

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Frizzled7 as an emerging target for cancer therapy

• Authors : King, Taj D.; Zhang, Wei; Suto, Mark J.

• Source: Cellular Signalling. April 2012, Vol. 24 Issue 4, p846, 6 p.

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Studies on Dibenzylamines as Inhibitors of Venezuelan Equine Encephalitis Virus.

• Authors : Nguyen, Theresa H.; Haese, Nicole N.; Madadi, Nikhil

• Source: ACS Infectious Diseases; 12/13/2019, Vol. 5 Issue 12, p2014-2028, 15p

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Development of small‐molecule tau‐SH3 interaction inhibitors that prevent amyloid‐β toxicity.

• Authors : Roth, Jonathan R; Rush, Travis; Pugh, Derian A

• Source: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2021 Supplement S9, Vol. 17, p1-1, 1p

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Effects of PD 128763, a New Potent Inhibitor of Poly(ADP-Ribose) Polymerase, on X-Ray-Induced Cellular Recovery Processes in Chinese Hamster V79 Cells

• Authors : Arundel-Suto, Carla M.; Scavone, Sylvia V.; Turner, William R.

• Source: Radiation Research. 126(3):367-371

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AlphaScreen HTS and live-cell bioluminescence resonance energy transfer (BRET) assays for identification of Tau-Fyn SH3 interaction inhibitors for alzheimer disease

• Authors : Cochran, J. Nicholas; Diggs, Pauleatha V.; Nebane, N. Miranda

• Source: Journal of Biomolecular Screening. Dec 2014, Vol. 19 Issue 10, 1338-1349

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Synthesis of Boxazomycin B and related analogs

• Authors : Suto, Mark J.; Turner, William R.

• Source: Tetrahedron Letters. Oct 2, 1995, Vol. 36 Issue 40, p7213, 4 p.

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Structure-activity relationships and cellular mechanism of action of small molecules that enhance the delivery of oligonucleotides.

• Authors : Juliano, Rudolph L; Wang, Ling; Tavares, Francis

• Source: Nucleic Acids Research; 2/28/2018, Vol. 46 Issue 4, p1601-1613, 13p

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Predicting radiotherapy response for patients with soft tissue sarcoma by developing a molecular signature.

• Authors : ZAIXIANG TANG; QINGHUA ZENG; YAN LI

• Source: Oncology Reports; Nov2017, Vol. 38 Issue 5, p2814-2824, 11p

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Rational design and development of a peptide inhibitor for the PD-1/PD-L1 interaction.

• Authors : Sambandam, Vijaya¹; Suto, Mark¹; Boohaker, Rebecca J.^1,2

• Source: Cancer Letters. Oct2018, Vol. 434, p11-21. 11p.

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Thrombospondin-1 regulation of latent TGF-β activation: A therapeutic target for fibrotic disease.

• Authors : Murphy-Ullrich, Joanne E.¹ ; Suto, Mark J.²

• Source: Matrix Biology. Aug2018, Vol. 68, p28-43. 16p.

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Discovery of Clinically Approved Agents That Promote Suppression of Cystic Fibrosis Transmembrane Conductance Regulator Nonsense Mutations.

• Authors : Mutyam, Venkateshwar; Ming Du; Xiaojiao Xue

Subjects: ANIMAL experimentation; CELL lines; CYSTIC fibrosis

• Source: American Journal of Respiratory & Critical Care Medicine; 11/1/2016, Vol. 194 Issue 9, p1092-1103, 12p, 1 Diagram, 1 Chart, 6 Graphs

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Discovery of a novel inhibitor of kinesin-like protein KIFC1.

• Authors : Wei Zhang; Ling Zhai; Yimin Wang

Subjects: BREAST cancer treatment; CANCER cells; NEOPLASTIC cell transformation

• Source: Biochemical Journal; 4/15/2016, Vol. 473 Issue 8, p1027-1035, 9p

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Consortia's critical role in developing medical countermeasures for re-emerging viral infections: a USA perspective.

• Authors : Everts, Maaike; Suto, Mark J; Painter, George R

• Source: Future Virology; Mar2016, Vol. 11 Issue 3, p187-195, 9p

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Inhibition of Transforming Growth Factor-β Activation Diminishes Tumor Progression and Osteolytic Bone Disease in Mouse Models of Multiple Myeloma

• Authors : Lu, Ailing; Pallero, Manuel A.; Lei, Weiqi

• Source: American Journal of Pathology; March 2016, Vol. 186 Issue: 3 p678-690, 13p

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A Historical Perspective

• Authors : Suto, Mark J.

Subjects: Biotechnology industry; Business; Pharmaceuticals and cosmetics industriesUnited States

• Source: BioPharm. Feb, 1998, Vol. 11 Issue 2, 28

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