Search Results

Synthesis of Novel Pyridine-Carboxylates as Small-Molecule Inhibitors of Human Aspartate/Asparagine-[beta]-Hydroxylase

• Authors : Brewitz, Lennart; Tumber, Anthony; Thalhammer, Armin

• Source: ChemMedChem. July 3, 2020, Vol. 15 Issue 13, p1139, 11 p.

Record details

Penicillin Derivatives Inhibit the SARS-CoV‑2 Main Protease by Reaction with Its Nucleophilic Cysteine.

• Authors : Malla, Tika R.; Brewitz, Lennart; Muntean, Dorian-Gabriel

• Source: Journal of Medicinal Chemistry; 6/9/2022, Vol. 65 Issue 11, p7682-7696, 15p

Record details

Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases

• Authors : Brewitz, Lennart; Nakashima, Yu; Tumber, Anthony

• Source: Journal of Fluorine Chemistry. July 2021, Vol. 247

Record details

Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins.

• Authors : Belle, Roman; Kamps, Jos J. A. G.; Poater, Jordi

Subjects: SMALL molecules; CARRIER proteins; OXYGENASES

• Source: Communications Chemistry; 3/7/2022, Vol. 5 Issue 1, p1-11, 11p

Record details

Structure‐Activity Studies Reveal Scope for Optimisation of Ebselen‐Type Inhibition of SARS‐CoV‐2 Main Protease.

• Authors : Thun‐Hohenstein, Siegfried T. D.; Suits, Timothy F.; Malla, Tika R.

• Source: ChemMedChem; 2/16/2022, Vol. 17 Issue 4, p1-5, 5p

Record details

First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53.

• Authors : Nowak, Radosław P.; Tumber, Anthony; Hendrix, Eline

• Source: Journal of Medicinal Chemistry; 12/9/2021, Vol. 64 Issue 23, p17031-17050, 20p

Record details

Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors.

• Authors : Shishodia, Shifali; Demetriades, Marina; Dong Zhang

• Source: Journal of Medicinal Chemistry; 11/25/2021, Vol. 64 Issue 22, p16609-16625, 17p

Record details

2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.

• Authors : Nakashima, Yu; Brewitz, Lennart; Tumber, Anthony

Subjects: DRUG target; OXYGENASES; HYPOXIA-inducible factors

• Source: Nature Communications; 11/10/2021, Vol. 12 Issue 1, p1-17, 17p

Record details

Discovery of SARS-CoV-2 Mpro peptide inhibitors from modelling substrate and ligand binding.

• Authors : Chan, H. T. Henry; Moesser, Marc A.; Walters, Rebecca K.

• Source: Chemical Science; 11/7/2021, Vol. 12 Issue 41, p13686-13703, 18p

Record details

Conformational plasticity of the ULK3 kinase domain.

• Authors : Mathea, Sebastian; Salah, Eidarus; Tallant, Cynthia

Subjects: PROTEIN kinases; KINASES; CYTOKINESIS

• Source: Biochemical Journal; Jul2021, Vol. 478 Issue 14, p2811-2823, 13p

Record details