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LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains

• Authors : Weng, Jui-Hung; Aoto, Phillip C.; Lorenz, Robin

• Source: PLoS Biology. February 22, 2022, Vol. 20 Issue 2, pe3001427.

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Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2

• Authors : Schmidt, Sven H.; Weng, Jui-Hung; Aoto, Phillip C.

• Source: Proceedings of the National Academy of Sciences of the United States. June 8, 2021, Vol. 118 Issue 23, p1BG, 12 p.

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Trypsiligase-Catalyzed Labeling of Proteins on Living Cells

• Authors : Liebscher, Sandra; Mathea, Sebastian; Aumuller, Tobias

• Source: ChemBioChem. April 6, 2021, Vol. 22 Issue 7, p1201, 4 p.

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Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5‑a]pyrimidine-Based Macrocycles.

• Authors : Kurz, Christian G.; Preuss, Franziska; Tjaden, Amelie

• Source: Journal of Medicinal Chemistry; 6/9/2022, Vol. 65 Issue 11, p7799-7817, 19p

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Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.

• Authors : Drewry, David H.; Annor-Gyamfi, Joel K.; Wells, Carrow I.

• Source: Journal of Medicinal Chemistry; 1/27/2022, Vol. 65 Issue 2, p1313-1328, 16p

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Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases

• Authors : Sheetz, Joshua B.; Mathea, Sebastian; Karvonen, Hanna

• Source: Molecular Cell. August 6, 2020, Vol. 79 Issue 3, 390

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Conformational plasticity of the ULK3 kinase domain.

• Authors : Mathea, Sebastian; Salah, Eidarus; Tallant, Cynthia

Subjects: PROTEIN kinases; KINASES; CYTOKINESIS

• Source: Biochemical Journal; Jul2021, Vol. 478 Issue 14, p2811-2823, 13p

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Regulation of the Minichromosome Maintenance Protein 3 (MCM3) Chromatin Binding by the Prolyl Isomerase Pin1

• Authors : Schumann, Michael; Malesevic, Miroslav; Hinze, Erik

• Source: Journal of Molecular Biology. Dec 7, 2018, Vol. 430 Issue 24, p5169.

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Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms.

• Authors : Malik, Asad U.; Karapetsas, Athanasios; Nirujogi, Raja S.

Subjects: PHORBOL esters; PARKINSON'S disease; PHOSPHORYLATION

• Source: Biochemical Journal; Feb2021, Vol. 478 Issue 3, p553-578, 26p

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Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID Subunit 1

• Authors : Suh, Junghyun L.; Watts, Brian; Stuckey, Jacob I.

• Source: Biochemistry. April 10, 2018, Vol. 57 Issue 14, 2140-2149

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