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Academic Journal

Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2.

Authors : Ferreira de Freitas, Renato; Liu, Yanli; Szewczyk, Magdalena M.

Source: Journal of Medicinal Chemistry; 2/11/2021, Vol. 64 Issue 3, p1584-1592, 9p

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Academic Journal

Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3–9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase.

Authors : Taylor, Alexandria P.; Swewczyk, Magdalena; Kennedy, Steven

Source: Journal of Medicinal Chemistry; 9/12/2019, Vol. 62 Issue 17, p7669-7683, 15p

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Academic Journal

A systematic analysis of atomic protein–ligand interactions in the PDB.

Authors : Ferreira de Freitas, Renato; Schapira, Matthieu

Source: MedChemComm; Oct2017, Vol. 8 Issue 10, p1970-1981, 12p

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Academic Journal

Methyltransferase Inhibitors: Competing with, or Exploiting the Bound Cofactor.

Authors : Ferreira de Freitas, Renato¹ (AUTHOR); Ivanochko, Danton^2,3 (AUTHOR); Schapira, Matthieu^2,4 (AUTHOR)

Source: Molecules. Dec2019, Vol. 24 Issue 24, p4492. 1p. 7 Diagrams, 2 Graphs.

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Academic Journal

Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6.

Authors : Yudao Shen; Szewczyk, Magdalena M.; Eram, Mohammad S.

Source: Journal of Medicinal Chemistry; Oct2016, Vol. 59 Issue 19, p9124-9139, 16p

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Academic Journal

Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening.

Authors : Ferreira de Freitas, Renato; Eram, Mohammad S.; Smil, David

Source: Journal of Medicinal Chemistry; Jul2016, Vol. 59 Issue 14, p6838-6847, 10p

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Academic Journal

Structural biology and chemistry of protein arginine methyltransferases.

Authors : Schapira, Matthieu; Ferreira de Freitas, Renato

Source: MedChemComm; 2014, Vol. 5 Issue 12, p1779-1788, 10p

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Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2.

Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3–9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase.

A systematic analysis of atomic protein–ligand interactions in the PDB.

Methyltransferase Inhibitors: Competing with, or Exploiting the Bound Cofactor.

Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6.

Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening.

Structural biology and chemistry of protein arginine methyltransferases.