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Academic Journal

Ketoheterocycle-based inhibitors of cathepsin K: A novel entry into the synthesis of peptidic ketoheterocycles

Authors : Tavares, Francis X.; Deaton, David N.; Miller, Aaron B.

Source: Bioorganic & Medicinal Chemistry Letters. Sept 1, 2005, Vol. 15 Issue 17, p3891, 5 p.

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Academic Journal

Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy

Authors : Thomson, Stephen A. ; Banker, Pierette¹; Bickett, D. Mark¹

Source: Bioorganic & Medicinal Chemistry Letters. Feb2009, Vol. 19 Issue 4, p1177-1182. 6p.

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Academic Journal

Anthranilimide-based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes: 1. Identification of 1-amino-1-cycloalkyl carboxylic acid headgroups

Authors : Sparks, Steven M. ; Banker, Pierette¹; Bickett, David M.¹

Source: Bioorganic & Medicinal Chemistry Letters. Feb2009, Vol. 19 Issue 3, p976-980. 5p.

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Academic Journal

Anthranilimide-based glycogen phosphorylase inhibitors for the treatment of Type 2 diabetes: 2. Optimization of serine and threonine ether amino acid residues

Authors : Sparks, Steven M. ; Banker, Pierette¹; Bickett, David M.¹

Source: Bioorganic & Medicinal Chemistry Letters. Feb2009, Vol. 19 Issue 3, p981-985. 5p.

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Academic Journal

Amino acid anthranilamide derivatives as a new class of glycogen phosphorylase inhibitors

Authors : Evans, Karen A.¹ ; Li, Yue H.¹; Coppo, Frank T.¹

Source: Bioorganic & Medicinal Chemistry Letters. Jul2008, Vol. 18 Issue 14, p4068-4071. 4p.

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Academic Journal

Acyclic, orally bioavailable ketone-based cathepsin K inhibitors

Authors : Barrett, David G.¹; Catalano, John G.¹; Deaton, David N.¹

Source: Bioorganic & Medicinal Chemistry Letters. Jan2007, Vol. 17 Issue 1, p22-27. 6p.

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Academic Journal

Synthesis and structure–activity relationships of 3-phenyl-2-propenamides as inhibitors of glycogen phosphorylase a

Authors : Li, Yue H.¹; Coppo, Frank T.¹; Evans, Karen A.¹

Source: Bioorganic & Medicinal Chemistry Letters. Nov2006, Vol. 16 Issue 22, p5892-5896. 5p.

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Academic Journal

The discovery and optimization of pyrimidinone-containing MCH R1 antagonists

Authors : Hertzog, Donald L. ; Al-Barazanji, Kamal A.¹; Bigham, Eric C.¹

Source: Bioorganic & Medicinal Chemistry Letters. Sep2006, Vol. 16 Issue 18, p4723-4727. 5p.

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Academic Journal

P2–P3 conformationally constrained ketoamide-based inhibitors of cathepsin K

Authors : Barrett, David G.¹; Boncek, Virginia M.²; Catalano, John G.¹

Source: Bioorganic & Medicinal Chemistry Letters. Aug2005, Vol. 15 Issue 15, p3540-3546. 7p.

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Academic Journal

Novel and potent cyclic cyanamide-based cathepsin K inhibitors

Authors : Deaton, David N.¹ ; Hassell, Anne M.²; McFadyen, Robert B.¹

Source: Bioorganic & Medicinal Chemistry Letters. Apr2005, Vol. 15 Issue 7, p1815-1819. 5p.

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