Analyses of big datasets signal important directions for the archaeology of religion in the Archaic to Mississippian Native North America Across North America, huge data accumulations derived from decades of cultural resource management studies, combined with old museum collections, provide archaeologists with unparalleled opportunities to explore new questions about the lives of ancient native peoples. For many years the topics of technology, economy, and political organization have received the most research attention, while ritual, religion, and symbolic expression have largely been ignored. This was often the case because researchers considered such topics beyond reach of their methods and data. In Archaeology and Ancient Religion in the American Midcontinent, editors Brad H. Koldehoff and Timothy R. Pauketat and their contributors demonstrate that this notion is outdated through their analyses of a series of large datasets from the midcontinent, ranging from tiny charred seeds to the cosmic alignments of mounds, they consider new questions about the religious practices and lives of native peoples. At the core of this volume are case studies that explore religious practices from the Cahokia area and surrounding Illinois uplands. Additional chapters explore these topics using data collected from sites and landscapes scattered along the Mississippi and Ohio River valleys. This innovative work facilitates a greater appreciation for, and understanding of, ancient native religious practices, especially their seamless connections to everyday life and livelihood. The contributors do not advocate for a reduced emphasis on technology, economy, and political organization; rather, they recommend expanding the scope of such studies to include considerations of how religious practices shaped the locations of sites, the character of artifacts, and the content and arrangement of sites and features. They also highlight analytical approaches that are applicable to archaeological datasets from across the Americas and beyond.