Diet-induced weight loss in obese children with asthma: a randomized controlled trial.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Subject Terms:
    • Abstract:
      Background Obesity is highly prevalent in asthmatic children and associated with worse clinical outcomes. Energy restriction to induce weight loss in asthmatic children has not been investigated in a randomized controlled trial ( RCT). Objective To assess if (1) weight loss can be achieved in obese asthmatic children using a dietary intervention; and (2) changes in asthma outcomes occur following diet-induced weight loss. Methods In a 10-week pilot RCT, obese asthmatic children, aged 8-17 years, were randomized to a wait-list control ( WLC) ( n = 15) or dietary-intervention group ( DIG) ( n = 13). Lung function, Asthma Control Questionnaire ( ACQ) score, and sputum and systemic inflammation were assessed at baseline and post-intervention. (Australian New Zealand Clinical Trials Registry: ACTRN12610000955011). Results Body mass index (BMI) z-score reduced significantly in the DIG vs. the WLC (−0.2 [−0.4, −0.1] vs. 0.0 [−0.1, 0.0], P = 0.014). Expiratory reserve volume (ERV) increased significantly within the DIG, but not compared to the WLC (0.7 [0.0, 1.0] L vs. 0.3 [0.0, 0.8] L, P = 0.355). ACQ improved significantly in the DIG, compared to the WLC (−0.4 [−0.7, 0.0] vs. 0.1 [0.0, 0.6], P = 0.004). Airway and systemic inflammation did not change within the DIG. In comparison, C-Reactive Protein (CRP) increased significantly in the WLC (−0.4 [−0.5, 0.4] vs. 0.7 [−0.1, 1.9], P = 0.037). Change (∆) in BMI z-score correlated with ∆CRP ( r = 0.47, P = 0.012) and ∆exhaled nitric oxide ( eNO) ( r = 0.46, P = 0.034), and ∆ACQ was associated with ∆CRP ( r = 0.43, P = 0.029). Conclusion and Clinical Relevance Dietary intervention can induce acute weight loss in obese asthmatic children with subsequent improvements in static lung function and asthma control. Systemic and airway inflammation did not change following weight loss. However, changes in BMI z-score were associated with changes in airway and systemic inflammation and this requires further investigation in a larger RCT. This is the first weight loss RCT conducted in obese asthmatic children. Diet-induced weight loss can achieve significant improvements in clinical outcomes for obese children with asthma. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Clinical & Experimental Allergy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)