Comparing population structure as inferred from genealogical versus genetic information.

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  • Additional Information
    • Subject Terms:
    • Author-Supplied Keywords:
      Fst
      genetic clustering methods
      genetic isolate
      kinship
      population structure
    • Abstract:
      Algorithms for inferring population structure from genetic data (ie, population assignment methods) have shown to effectively recognize genetic clusters in human populations. However, their performance in identifying groups of genealogically related individuals, especially in scanty-differentiated populations, has not been tested empirically thus far. For this study, we had access to both genealogical and genetic data from two closely related, isolated villages in southern Italy. We found that nearly all living individuals were included in a single pedigree, with multiple inbreeding loops. Despite Fst between villages being a low 0.008, genetic clustering analysis identified two clusters roughly corresponding to the two villages. Average kinship between individuals (estimated from genealogies) increased at increasing values of group membership (estimated from the genetic data), showing that the observed genetic clusters represent individuals who are more closely related to each other than to random members of the population. Further, average kinship within clusters and Fst between clusters increases with increasingly stringent membership threshold requirements. We conclude that a limited number of genetic markers is sufficient to detect structuring, and that the results of genetic analyses faithfully mirror the structuring inferred from detailed analyses of population genealogies, even when Fst values are low, as in the case of the two villages. We then estimate the impact of observed levels of population structure on association studies using simulated data. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of European Journal of Human Genetics is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • ISSN:
      1018-4813
    • Accession Number:
      10.1038/ejhg.2009.97
    • Accession Number:
      45272039
  • Citations
    • ABNT:
      COLONNA, V. et al. Comparing population structure as inferred from genealogical versus genetic information. European Journal of Human Genetics, [s. l.], v. 17, n. 12, p. 1635–1641, 2009. DOI 10.1038/ejhg.2009.97. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hch&AN=45272039. Acesso em: 24 nov. 2020.
    • AMA:
      Colonna V, Nutile T, Ferrucci RR, et al. Comparing population structure as inferred from genealogical versus genetic information. European Journal of Human Genetics. 2009;17(12):1635-1641. doi:10.1038/ejhg.2009.97
    • APA:
      Colonna, V., Nutile, T., Ferrucci, R. R., Fardella, G., Aversano, M., Barbujani, G., & Ciullo, M. (2009). Comparing population structure as inferred from genealogical versus genetic information. European Journal of Human Genetics, 17(12), 1635–1641. https://doi.org/10.1038/ejhg.2009.97
    • Chicago/Turabian: Author-Date:
      Colonna, Vincenza, Teresa Nutile, Ronald R Ferrucci, Giulio Fardella, Mario Aversano, Guido Barbujani, and Marina Ciullo. 2009. “Comparing Population Structure as Inferred from Genealogical versus Genetic Information.” European Journal of Human Genetics 17 (12): 1635–41. doi:10.1038/ejhg.2009.97.
    • Harvard:
      Colonna, V. et al. (2009) ‘Comparing population structure as inferred from genealogical versus genetic information’, European Journal of Human Genetics, 17(12), pp. 1635–1641. doi: 10.1038/ejhg.2009.97.
    • Harvard: Australian:
      Colonna, V, Nutile, T, Ferrucci, RR, Fardella, G, Aversano, M, Barbujani, G & Ciullo, M 2009, ‘Comparing population structure as inferred from genealogical versus genetic information’, European Journal of Human Genetics, vol. 17, no. 12, pp. 1635–1641, viewed 24 November 2020, .
    • MLA:
      Colonna, Vincenza, et al. “Comparing Population Structure as Inferred from Genealogical versus Genetic Information.” European Journal of Human Genetics, vol. 17, no. 12, Dec. 2009, pp. 1635–1641. EBSCOhost, doi:10.1038/ejhg.2009.97.
    • Chicago/Turabian: Humanities:
      Colonna, Vincenza, Teresa Nutile, Ronald R Ferrucci, Giulio Fardella, Mario Aversano, Guido Barbujani, and Marina Ciullo. “Comparing Population Structure as Inferred from Genealogical versus Genetic Information.” European Journal of Human Genetics 17, no. 12 (December 2009): 1635–41. doi:10.1038/ejhg.2009.97.
    • Vancouver/ICMJE:
      Colonna V, Nutile T, Ferrucci RR, Fardella G, Aversano M, Barbujani G, et al. Comparing population structure as inferred from genealogical versus genetic information. European Journal of Human Genetics [Internet]. 2009 Dec [cited 2020 Nov 24];17(12):1635–41. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hch&AN=45272039