Pain freedom after 2 hours should be the primary outcome in controlled trials treating migraine attacks.

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  • Additional Information
    • Subject Terms:
    • Author-Supplied Keywords:
      controlled trials
      headache relief
      Migraine attack
      pain freedom
      treatment
    • Abstract:
      Background: Pain freedom after 2 hours is the recommended primary endpoint by the International Headache Society in randomized trials investigating drug treatment of acute migraine attacks. In order to demonstrate an early effect of a drug, some drug companies, however, have promoted headache relief (improvement from severe or moderate pain to mild or no pain) at earlier time points than 2 hours as outcome parameter.Methods and Results: We analyzed the relationship between pain freedom and headache relief in acute migraine trials and observed that persistent mild headache constituted 90% of headache relief after 0.5 hour and 40% of headache relief after 2 hours.Conclusion: Headache relief at 2 hours should in our view only be used as an outcome measure for comparison with historic data. Prior to 2 hours, headache relief varies with time from intake and the therapeutic gain is very small. Therefore, pain freedom should be used at these early time points. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • ISSN:
      0333-1024
    • Accession Number:
      10.1177/0333102420941827
    • Accession Number:
      146465108
  • Citations
    • ABNT:
      TFELT-HANSEN, P.; DIENER, H.-C. Pain freedom after 2 hours should be the primary outcome in controlled trials treating migraine attacks. Cephalalgia, [s. l.], v. 40, n. 12, p. 1331–1335, 2020. DOI 10.1177/0333102420941827. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hch&AN=146465108. Acesso em: 26 nov. 2020.
    • AMA:
      Tfelt-Hansen P, Diener H-C. Pain freedom after 2 hours should be the primary outcome in controlled trials treating migraine attacks. Cephalalgia. 2020;40(12):1331-1335. doi:10.1177/0333102420941827
    • APA:
      Tfelt-Hansen, P., & Diener, H.-C. (2020). Pain freedom after 2 hours should be the primary outcome in controlled trials treating migraine attacks. Cephalalgia, 40(12), 1331–1335. https://doi.org/10.1177/0333102420941827
    • Chicago/Turabian: Author-Date:
      Tfelt-Hansen, Peer, and Hans-Christoph Diener. 2020. “Pain Freedom after 2 Hours Should Be the Primary Outcome in Controlled Trials Treating Migraine Attacks.” Cephalalgia 40 (12): 1331–35. doi:10.1177/0333102420941827.
    • Harvard:
      Tfelt-Hansen, P. and Diener, H.-C. (2020) ‘Pain freedom after 2 hours should be the primary outcome in controlled trials treating migraine attacks’, Cephalalgia, 40(12), pp. 1331–1335. doi: 10.1177/0333102420941827.
    • Harvard: Australian:
      Tfelt-Hansen, P & Diener, H-C 2020, ‘Pain freedom after 2 hours should be the primary outcome in controlled trials treating migraine attacks’, Cephalalgia, vol. 40, no. 12, pp. 1331–1335, viewed 26 November 2020, .
    • MLA:
      Tfelt-Hansen, Peer, and Hans-Christoph Diener. “Pain Freedom after 2 Hours Should Be the Primary Outcome in Controlled Trials Treating Migraine Attacks.” Cephalalgia, vol. 40, no. 12, Oct. 2020, pp. 1331–1335. EBSCOhost, doi:10.1177/0333102420941827.
    • Chicago/Turabian: Humanities:
      Tfelt-Hansen, Peer, and Hans-Christoph Diener. “Pain Freedom after 2 Hours Should Be the Primary Outcome in Controlled Trials Treating Migraine Attacks.” Cephalalgia 40, no. 12 (October 15, 2020): 1331–35. doi:10.1177/0333102420941827.
    • Vancouver/ICMJE:
      Tfelt-Hansen P, Diener H-C. Pain freedom after 2 hours should be the primary outcome in controlled trials treating migraine attacks. Cephalalgia [Internet]. 2020 Oct 15 [cited 2020 Nov 26];40(12):1331–5. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hch&AN=146465108