Low complication rate in immunocompromised children with varicella-zoster virus infections in a single centre.

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  • Additional Information
    • Subject Terms:
    • Subject Terms:
    • Author-Supplied Keywords:
      chickenpox
      herpes zoster
      immunocompromised
      outcome
      varicella‐zoster virus
    • Abstract:
      Aim: Recent studies focusing on morbidity and mortality rates of immunocompromised children with varicella-zoster virus (VZV) infections are scarce. We aimed to summarise our experience.Methods: The study was a retrospective analysis of the medical records of children, who were admitted to Hadassah-Hebrew University Medical Centre, Jerusalem, Israel, during the period of 2008-2016. Data regarding baseline characteristics, treatment and outcome were extracted from patient's medical files.Results: We enrolled 74 patients (43% males) with a mean age of 8 (1-19) years. Most patients (72%) had no reported complications. Clinical outcome was favourable with 73 (99%) patients who had completely recovered and none died. Multivariable analysis identified the presence of fever (P = .005 and 0.02; hazard ratio (HR) 7.72 and 17.61, for total and herpes zoster groups, respectively) and prolonged interval period from clinical presentation to treatment onset (P = .021 and 0.025; HR 1.68 and 2.26, respectively), as associated with higher rates of complications.Conclusion: Our results found low complication rate of VZV-associated infections in immunocompromised children admitted to a single centre. This should encourage conducting further large multicentre studies evaluating management of low-risk patients with oral acyclovir treatment. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • ISSN:
      0803-5253
    • Accession Number:
      10.1111/apa.15118
    • Accession Number:
      143852113
  • Citations
    • ABNT:
      SHAMRIZ, O. et al. Low complication rate in immunocompromised children with varicella-zoster virus infections in a single centre. Acta Paediatrica, [s. l.], v. 109, n. 7, p. 1409–1416, 2020. DOI 10.1111/apa.15118. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hch&AN=143852113. Acesso em: 28 nov. 2020.
    • AMA:
      Shamriz O, Ben AR, Averbuch D, Reif S, Ben-Ami R. Low complication rate in immunocompromised children with varicella-zoster virus infections in a single centre. Acta Paediatrica. 2020;109(7):1409-1416. doi:10.1111/apa.15118
    • APA:
      Shamriz, O., Ben, A. R., Averbuch, D., Reif, S., & Ben-Ami, R. (2020). Low complication rate in immunocompromised children with varicella-zoster virus infections in a single centre. Acta Paediatrica, 109(7), 1409–1416. https://doi.org/10.1111/apa.15118
    • Chicago/Turabian: Author-Date:
      Shamriz, Oded, Ami, Roni Ben, Diana Averbuch, Shimon Reif, and Roni Ben-Ami. 2020. “Low Complication Rate in Immunocompromised Children with Varicella-Zoster Virus Infections in a Single Centre.” Acta Paediatrica 109 (7): 1409–16. doi:10.1111/apa.15118.
    • Harvard:
      Shamriz, O. et al. (2020) ‘Low complication rate in immunocompromised children with varicella-zoster virus infections in a single centre’, Acta Paediatrica, 109(7), pp. 1409–1416. doi: 10.1111/apa.15118.
    • Harvard: Australian:
      Shamriz, O, Ben, AR, Averbuch, D, Reif, S & Ben-Ami, R 2020, ‘Low complication rate in immunocompromised children with varicella-zoster virus infections in a single centre’, Acta Paediatrica, vol. 109, no. 7, pp. 1409–1416, viewed 28 November 2020, .
    • MLA:
      Shamriz, Oded, et al. “Low Complication Rate in Immunocompromised Children with Varicella-Zoster Virus Infections in a Single Centre.” Acta Paediatrica, vol. 109, no. 7, July 2020, pp. 1409–1416. EBSCOhost, doi:10.1111/apa.15118.
    • Chicago/Turabian: Humanities:
      Shamriz, Oded, Ami, Roni Ben, Diana Averbuch, Shimon Reif, and Roni Ben-Ami. “Low Complication Rate in Immunocompromised Children with Varicella-Zoster Virus Infections in a Single Centre.” Acta Paediatrica 109, no. 7 (July 2020): 1409–16. doi:10.1111/apa.15118.
    • Vancouver/ICMJE:
      Shamriz O, Ben AR, Averbuch D, Reif S, Ben-Ami R. Low complication rate in immunocompromised children with varicella-zoster virus infections in a single centre. Acta Paediatrica [Internet]. 2020 Jul [cited 2020 Nov 28];109(7):1409–16. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hch&AN=143852113