Freedom isn't always free: immunoglobulin free light chains promote renal fibrosis.

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  • Author(s): Taylor, Erin B.; Ryan, Michael J.
  • Source:
    Journal of Clinical Investigation. Jul2019, Vol. 129 Issue 7, p2660-2662. 3p.
  • Document Type:
    journal article
  • Additional Information
    • Subject Terms:
    • Abstract:
      Multiple myeloma (MM) is a relatively common hematologic malignancy, and up to half of patients with MM present with renal dysfunction at the time of diagnosis. MM-associated renal injury has been linked to an excess level of monoclonal immunoglobulin free light chains (FLCs) in the circulation; however, it is not clear how these FLCs drive renal pathology. In this issue of the JCI, Ying et al. unravel a novel mechanism by which FLCs mediate renal injury in MM by inducing fibrotic and inflammatory pathways in the kidney. Specifically, FLC-mediated production of H2O2 was shown to activate JAK2/STAT1 signaling, increase production of IL-1β via induction of capsase-1, and promote activation of TGF-β via αvβ6 integrin. Moreover, the authors identified a tryptophan residue within a specific monoclonal FLC that was required for optimal H2O2 production and downstream signaling. A better understanding of the drivers of MM-associated renal injury has potential for the identification of promising therapeutic targets. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Journal of Clinical Investigation is the property of American Society for Clinical Investigation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • ISSN:
      0021-9738
    • Accession Number:
      10.1172/JCI129704
    • Accession Number:
      137332830
  • Citations
    • ABNT:
      TAYLOR, E. B.; RYAN, M. J. Freedom isn’t always free: immunoglobulin free light chains promote renal fibrosis. Journal of Clinical Investigation, [s. l.], v. 129, n. 7, p. 2660–2662, 2019. DOI 10.1172/JCI129704. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hch&AN=137332830. Acesso em: 1 dez. 2020.
    • AMA:
      Taylor EB, Ryan MJ. Freedom isn’t always free: immunoglobulin free light chains promote renal fibrosis. Journal of Clinical Investigation. 2019;129(7):2660-2662. doi:10.1172/JCI129704
    • APA:
      Taylor, E. B., & Ryan, M. J. (2019). Freedom isn’t always free: immunoglobulin free light chains promote renal fibrosis. Journal of Clinical Investigation, 129(7), 2660–2662. https://doi.org/10.1172/JCI129704
    • Chicago/Turabian: Author-Date:
      Taylor, Erin B., and Michael J. Ryan. 2019. “Freedom Isn’t Always Free: Immunoglobulin Free Light Chains Promote Renal Fibrosis.” Journal of Clinical Investigation 129 (7): 2660–62. doi:10.1172/JCI129704.
    • Harvard:
      Taylor, E. B. and Ryan, M. J. (2019) ‘Freedom isn’t always free: immunoglobulin free light chains promote renal fibrosis’, Journal of Clinical Investigation, 129(7), pp. 2660–2662. doi: 10.1172/JCI129704.
    • Harvard: Australian:
      Taylor, EB & Ryan, MJ 2019, ‘Freedom isn’t always free: immunoglobulin free light chains promote renal fibrosis’, Journal of Clinical Investigation, vol. 129, no. 7, pp. 2660–2662, viewed 1 December 2020, .
    • MLA:
      Taylor, Erin B., and Michael J. Ryan. “Freedom Isn’t Always Free: Immunoglobulin Free Light Chains Promote Renal Fibrosis.” Journal of Clinical Investigation, vol. 129, no. 7, July 2019, pp. 2660–2662. EBSCOhost, doi:10.1172/JCI129704.
    • Chicago/Turabian: Humanities:
      Taylor, Erin B., and Michael J. Ryan. “Freedom Isn’t Always Free: Immunoglobulin Free Light Chains Promote Renal Fibrosis.” Journal of Clinical Investigation 129, no. 7 (July 2019): 2660–62. doi:10.1172/JCI129704.
    • Vancouver/ICMJE:
      Taylor EB, Ryan MJ. Freedom isn’t always free: immunoglobulin free light chains promote renal fibrosis. Journal of Clinical Investigation [Internet]. 2019 Jul [cited 2020 Dec 1];129(7):2660–2. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hch&AN=137332830