Paediatric community‐acquired bacteraemia, pneumococcal invasive disease and antibiotic resistance fell after the pneumococcal conjugate vaccine was introduced.

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  • Additional Information
    • Subject Terms:
    • Subject Terms:
    • Author-Supplied Keywords:
      Community‐acquired bacteraemia
      Invasive pneumococcal disease
      Pneumococcal conjugate vaccine
      Serotypes
      Streptococcus pneumoniae
    • Abstract:
      Aim: This study examined the impact of the routine pneumococcal conjugate vaccination (PCV) on childhood community‐acquired bacteraemia (CAB) and antibiotic resistance patterns in Israeli children. Methods: Israel added the PCV vaccine to its national immunisation programme in July 2009. We retrospectively analysed the medical records of all patients with CAB under 18 years at three children's hospitals in Tel Aviv and Jerusalem from 2007 to 2015. The microbiological data, clinical presentation, pneumococcal serotype distribution, antibiotic susceptibility and outcomes of infections were compared before and after the vaccine was introduced. Results: There were 511 904 emergency department visits and 125 922 children were hospitalised. Of those, 238 had CAB before vaccination was introduced (mean age 17 months) and 316 had CAB after the introduction (mean age 21 months). Emergency department presentations for CAB fell from 141.8 to 91.8 per 100 000 visits: a relative risk reduction (RRR) of 35%. Hospitalisations for CAB decreased from 430 to 337 per 100 000 admissions: an RRR of 22%. Hospitalisations due to Staphylococcus aureus increased significantly and penicillin nonsusceptible blood Streptococcus pneumoniae isolates decreased significantly. Conclusion: Introducing national pneumococcal conjugate vaccination significantly changed the epidemiology of CAB, with reduced antibiotic‐resistant Streptococcus pneumoniae and increased hospitalisation rates for Staphylococcus aureus infections. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • Full Text Word Count:
      6242
    • ISSN:
      0803-5253
    • Accession Number:
      10.1111/apa.14670
    • Accession Number:
      137054056
  • Citations
    • ABNT:
      BERGER, Y. et al. Paediatric community‐acquired bacteraemia, pneumococcal invasive disease and antibiotic resistance fell after the pneumococcal conjugate vaccine was introduced. Acta Paediatrica, [s. l.], v. 108, n. 7, p. 1321–1328, 2019. DOI 10.1111/apa.14670. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hch&AN=137054056. Acesso em: 4 dez. 2020.
    • AMA:
      Berger Y, Adler A, Ariel T, Rokney A, Averbuch D, Grisaru SG. Paediatric community‐acquired bacteraemia, pneumococcal invasive disease and antibiotic resistance fell after the pneumococcal conjugate vaccine was introduced. Acta Paediatrica. 2019;108(7):1321-1328. doi:10.1111/apa.14670
    • APA:
      Berger, Y., Adler, A., Ariel, T., Rokney, A., Averbuch, D., & Grisaru, S. G. (2019). Paediatric community‐acquired bacteraemia, pneumococcal invasive disease and antibiotic resistance fell after the pneumococcal conjugate vaccine was introduced. Acta Paediatrica, 108(7), 1321–1328. https://doi.org/10.1111/apa.14670
    • Chicago/Turabian: Author-Date:
      Berger, Yael, Amos Adler, Tenenbaum Ariel, Assaf Rokney, Diana Averbuch, and Soen, Galia Grisaru. 2019. “Paediatric Community‐acquired Bacteraemia, Pneumococcal Invasive Disease and Antibiotic Resistance Fell after the Pneumococcal Conjugate Vaccine Was Introduced.” Acta Paediatrica 108 (7): 1321–28. doi:10.1111/apa.14670.
    • Harvard:
      Berger, Y. et al. (2019) ‘Paediatric community‐acquired bacteraemia, pneumococcal invasive disease and antibiotic resistance fell after the pneumococcal conjugate vaccine was introduced’, Acta Paediatrica, 108(7), pp. 1321–1328. doi: 10.1111/apa.14670.
    • Harvard: Australian:
      Berger, Y, Adler, A, Ariel, T, Rokney, A, Averbuch, D & Grisaru, SG 2019, ‘Paediatric community‐acquired bacteraemia, pneumococcal invasive disease and antibiotic resistance fell after the pneumococcal conjugate vaccine was introduced’, Acta Paediatrica, vol. 108, no. 7, pp. 1321–1328, viewed 4 December 2020, .
    • MLA:
      Berger, Yael, et al. “Paediatric Community‐acquired Bacteraemia, Pneumococcal Invasive Disease and Antibiotic Resistance Fell after the Pneumococcal Conjugate Vaccine Was Introduced.” Acta Paediatrica, vol. 108, no. 7, July 2019, pp. 1321–1328. EBSCOhost, doi:10.1111/apa.14670.
    • Chicago/Turabian: Humanities:
      Berger, Yael, Amos Adler, Tenenbaum Ariel, Assaf Rokney, Diana Averbuch, and Soen, Galia Grisaru. “Paediatric Community‐acquired Bacteraemia, Pneumococcal Invasive Disease and Antibiotic Resistance Fell after the Pneumococcal Conjugate Vaccine Was Introduced.” Acta Paediatrica 108, no. 7 (July 2019): 1321–28. doi:10.1111/apa.14670.
    • Vancouver/ICMJE:
      Berger Y, Adler A, Ariel T, Rokney A, Averbuch D, Grisaru SG. Paediatric community‐acquired bacteraemia, pneumococcal invasive disease and antibiotic resistance fell after the pneumococcal conjugate vaccine was introduced. Acta Paediatrica [Internet]. 2019 Jul [cited 2020 Dec 4];108(7):1321–8. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hch&AN=137054056