Structure--activity relationships of dinucleotides: Potent and selective agonists of P2Y receptors

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  • Additional Information
    • Publication Information:
      Springer
    • Publication Date:
      2005
    • Abstract:
      Dinucleoside polyphosphates act as agonists on purinergic P2Y receptors to mediate a variety of cellular processes. Symmetrical, naturally occurring purine dinucleotides are found in most living cells and their actions are generally known. Unsymmetrical purine dinucleotides and all pyrimidine containing dinucleotides, however, are not as common and therefore their actions are not well understood. To carry out a thorough examination of the activities and specificities of these dinucleotides, a robust method of synthesis was developed to allow manipulation of either nucleoside of the dinucleotide as well as the phosphate chain lengths. Adenosine containing dinucleotides exhibit some level of activity on P2Y.sub.1 while uridine containing dinucleotides have some level of agonist response on P2Y.sub.2 and P2Y.sub.6. The length of the linking phosphate chain determines a different specificity diphosphates are most accurately mimicked by dinucleoside triphosphates and triphosphates most resemble dinucleoside tetraphosphates. The pharmacological activities and relative metabolic stabilities of these dinucleotides are reported with their potential therapeutic applications being discussed.
    • ISSN:
      1573-9538
    • Rights:
      Copyright 2005 Gale, Cengage Learning. All rights reserved.
      COPYRIGHT 2005 Springer
    • Accession Number:
      edsgcl.171814503
  • Citations
    • ABNT:
      SHAVER, S. R. et al. Structure--activity relationships of dinucleotides: Potent and selective agonists of P2Y receptors. Purinergic Signalling, [s. l.], n. 2, p. 183, 2005. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsgao&AN=edsgcl.171814503. Acesso em: 12 ago. 2020.
    • AMA:
      Shaver SR, Rideout JL, Pendergast W, et al. Structure--activity relationships of dinucleotides: Potent and selective agonists of P2Y receptors. Purinergic Signalling. 2005;(2):183. Accessed August 12, 2020. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsgao&AN=edsgcl.171814503
    • APA:
      Shaver, S. R., Rideout, J. L., Pendergast, W., Douglass, J. G., Brown, E. G., Boyer, J. L., Patel, R. I., Redick, C. C., Jones, A. C., Picher, M., & Yerxa, B. R. (2005). Structure--activity relationships of dinucleotides: Potent and selective agonists of P2Y receptors. Purinergic Signalling, 2, 183.
    • Chicago/Turabian: Author-Date:
      Shaver, Sammy R., Janet L. Rideout, William Pendergast, James G. Douglass, Edward G. Brown, Jose L. Boyer, Roshni I. Patel, et al. 2005. “Structure--Activity Relationships of Dinucleotides: Potent and Selective Agonists of P2Y Receptors.” Purinergic Signalling, no. 2: 183. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsgao&AN=edsgcl.171814503.
    • Harvard:
      Shaver, S. R. et al. (2005) ‘Structure--activity relationships of dinucleotides: Potent and selective agonists of P2Y receptors’, Purinergic Signalling, (2), p. 183. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsgao&AN=edsgcl.171814503 (Accessed: 12 August 2020).
    • Harvard: Australian:
      Shaver, SR, Rideout, JL, Pendergast, W, Douglass, JG, Brown, EG, Boyer, JL, Patel, RI, Redick, CC, Jones, AC, Picher, M & Yerxa, BR 2005, ‘Structure--activity relationships of dinucleotides: Potent and selective agonists of P2Y receptors’, Purinergic Signalling, no. 2, p. 183, viewed 12 August 2020, .
    • MLA:
      Shaver, Sammy R., et al. “Structure--Activity Relationships of Dinucleotides: Potent and Selective Agonists of P2Y Receptors.” Purinergic Signalling, no. 2, 2005, p. 183. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsgao&AN=edsgcl.171814503.
    • Chicago/Turabian: Humanities:
      Shaver, Sammy R., Janet L. Rideout, William Pendergast, James G. Douglass, Edward G. Brown, Jose L. Boyer, Roshni I. Patel, et al. “Structure--Activity Relationships of Dinucleotides: Potent and Selective Agonists of P2Y Receptors.” Purinergic Signalling, no. 2 (2005): 183. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsgao&AN=edsgcl.171814503.
    • Vancouver/ICMJE:
      Shaver SR, Rideout JL, Pendergast W, Douglass JG, Brown EG, Boyer JL, et al. Structure--activity relationships of dinucleotides: Potent and selective agonists of P2Y receptors. Purinergic Signalling [Internet]. 2005 [cited 2020 Aug 12];(2):183. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsgao&AN=edsgcl.171814503